| 摘要: |
| 采用MTT法、HE染色、DNA电泳、TUNEL法和TRAP法（端粒重复序列扩增法），研究原花青素对人肝癌细胞SMMC-7721株凋亡及端粒酶活性的影响，探讨了其抗癌机制。结果表明，原花青素可抑制SMMC-7721肿瘤细胞增殖，诱导细胞凋亡，降低细胞端粒酶活性。说明原花青素具有诱导肿瘤细胞凋亡和降低肿瘤细胞端粒酶活性2种抗肿瘤作用。 |
| 关键词: 原花青素 肝癌细胞 细胞凋亡 端粒酶 |
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| Effect of proanthocyanidins on apoptosis and telomerase activity in SMMC-7721 human hepatocellular carcinoma |
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| Abstract: |
| To illustrate the effect of proanthocyanidins on apoptosis and telomerase activity in hepatocellular carcinoma as well as its antitumor mechanism,the effect of PC on SMMC-7721 cell line in vitro was studied by using MTT method,HE dying,DNA electrophoresis,TUNEL and TRAP (telomeric repeat amplification protocol).PC inhibited the growth of SMMC-7721 cell line by inducing apoptosis and down regulating the telomerase activity. |
| Key words: proanthocyanidins hepatocellar carcinoma apoptosis telomerase |
