| 摘要: |
| [目的]寻找更高活性的芳香二脒类抑菌化合物.[方法]以对氰基苯酚、1,3二溴丙烷和1,4二溴丁烷为原料,合成了A3、B3、B4、C3、C4、D3、D4和E3 8个丙烷脒衍生物,用1H-NMR和MS鉴定了其结构,用生长速率法和黄瓜真叶法测定了其活性,并与丙烷脒进行了比较.[结果]生长速率法测试表明,8种丙烷脒衍生物对番茄灰霉病菌(Botrytis cinerea)菌丝生长均具有较强的抑制作用,其中N,N-二正丙基丙烷脒(B3)、N,N-二正丙基丁烷脒(B4)、N,N-二异丙基丙烷脒(C3)、N,N-二异丁基丁烷脒(D3)对番茄灰霉病菌生长抑制的毒力均高于丙烷脒,其EC50为0.304 3～3.473 0 mg/L;黄瓜真叶法测定表明,50 mg/L剂量下B3、B4、C3的3d保护效果均在60%以上,优于丙烷脒处理的57.55%;B3、B4的3 d治疗效果分别为71.70%和68.87%,与丙烷脒防效(64.15%)相当.[结论]B3、B4较丙烷脒抑菌活性有较大提高,有望成为丙烷脒产品的更新品种. |
| 关键词: 丙烷脒 芳香二脒类 番茄灰霉病菌 抑菌活性 |
| DOI： |
| 分类号:S652.905 |
| 基金项目:国家“十五”科技攻关重大专项（2002BA516A04)；西北农林科技大学科研专项 |
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| Propamidine analogs synthesis and fungicidal bioactivity |
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LI Jian-ming,ZOU Zhi-rong,HUANG Zhi,LI Jian-ming,ZOU Zhi-rong,HUANG Zhi,LI Jian-ming,ZOU Zhi-rong,HUANG Zhi
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| Abstract: |
| 【Objective】 The research is to find more compounds with antifungal activity.【Method】 Eight propenaindine analogs A3,B3,B4,C3,C4,D3,D4 and E3 were synthesized from 4-cyanophenol and a，ωdibromopane.All compounds were confirmed by 1H-NMR and MS.The inhibitory effects were studied with the mycelial growth rate method.【Result】 The results showed that four compounds such as N,N-bispropylpropamidine (B3),N,N-bispropylbutylamidine (B4),N,N-diisopropylpropamidine (C3),N,N-disisobutylbuytlamidine (D3),had high inhibitory effect on the growth of Botrytis cinerea,with EC50 ranging from 0.241 8 mg/L to 3.473 0 mg/L,higher than propamidine;the protective and therapeutical efficacy of B3,B4 and C3 on leaves of cucumber all higher than that of propamidine.【Conclusion】 B3 and B4 own more potent activity than propamidine and can be used to substitute propamidine. |
| Key words: propamidine aromatic diamidino Botrytis cinerea Anti-bacterial activity |
