| 摘要: |
| 用反-1-碘-3-三甲硅氧基-1-辛烯制备的锌试剂与2-(6-甲氧羰己基)-4-(2-四氢吡喃氧基)-环戊-2-烯酮,经1,4-加成反应合成了前列腺素E1甲酯,这表明用有机锌试剂通过1,4-加成反应合成前列腺素E类化合物是可行的.对其加成反应条件的分析显示,在CuCN作用下,其加成反应产率可提高约12%. |
| 关键词: 有机锌 1,4-加成反应 前列腺素E1甲酯 有机合成 |
| DOI： |
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| Synthesis of prostaglandin E1 derivatives by 1,4-addition of an organozinc reagent |
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| Abstract: |
| Preparation of prostaglandin E1 methyl ester was accomplished by 1,4-addition reaction of organozinc reagent made from 1-iodo-3-trimethysiloxy-1-octene with 2-(6-methoxylcarbonylhexyl)-4-(2-tetrahydro-pyranyloxy)-2-cyclopentenone.It indicates it is possible that prostaglandin E compounds could be synthesized with 1,4-addition reaction of organozinc agent.Under catalysis of CuCN,the yield could increase 12% in the 1,4-addition reaction. |
| Key words: organozinc 1,4 addition reaction prostaglandin E1 methyl ester organic synthesis |
