| 摘要: |
| 以四苯硼钠为电活性物质,邻苯二甲酸二丁酯为增塑剂与5%的聚氯乙烯四氢呋喃溶液混合,涂覆在离子敏感场效应晶体管(ISFET)的栅极上,制得一种对利多卡因响应的药物敏感离子场效应晶体管传感器(Drug FET)。该传感器测定利多卡因的线性范围为0. 03～10 mmol·L-1,斜率为59. 5 mV/pc,适宜pH为2. 5～6. 0,检测下限为10μmol·L-1.用其分析盐酸利多卡因注射液含量,结果与药典方法相一致。 |
| 关键词: 药物分析，利多卡因，离子敏感场效应晶体管 |
| DOI： |
| 分类号:O657.15 |
| 基金项目:陕西省教委科学基金资助项目 |
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| Development and Application of Lidocaine FTES |
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| Abstract: |
| A kind of lidocaine drug FETS by the combination of ion sensitive field
effect transistor (ISFET) and drug sensitive membrane was developed with sodium tetraphenyl borate as electric active materials,DBP as plasticizer with 5% of PVC of tetrahydrofuran solution deposited on the ISFET gate area.The sensors response to lidocaine with a slope of 59. 5 mV/pc detected out the concentration ranges of 0. 03～1. 0 mmol·L-1 at pH ranges 2. 5～6. 0 with the lower detection limit of 10 μmol·L-1.The
results obtained in the determination of lidocaine in injection hydrochloride agree with
those by the pharmacopoeia method. |
| Key words: drug analysis,lidocaine,ion sensitive field effect transistor |
