| 摘要: |
| 通过3组成年奶山羊每周一次口服不同剂量的亚硒酸钠，历时49d的实验，临床症状逐渐加重，心血管、泌尿、呼吸等系统均受损害，组织病变程度依次为肝脏＞肾脏＞心脏＞脾脏＞肺脏＞淋巴结＞胰脏＞大脑。主要病变为组织细胞变性、分解和坏死，细胞核变形，染色体减少，线粒体嵴稀疏或消失，毛细血管扩张充血、出血和水肿。表明各组织器官对硒的敏感性不同，肝、肾等组织病理变化可以作为奶山羊硒中毒诊断的参考依据。 |
| 关键词: 奶山羊，硒，硒中毒 |
| DOI： |
| 分类号:S858.266.9 |
| 基金项目:国家教委优秀年轻教师基金项目 |
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| Study on the Clinic and Pathological Changes in Milk Goats Associated with Selenium Intoxication |
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Li Guoqin Wang Jianhua Cao Guangrong Xue Dengmin Ding Boliang Zhang Li Pu Guofcng Jin Yuli JiXiaolin,Li Guoqin Wang Jianhua Cao Guangrong Xue Dengmin Ding Boliang Zhang Li Pu Guofcng Jin Yuli JiXiaolin,Li Guoqin Wang Jianhua Cao Guangrong Xue Dengmin Ding Boliang Zhang Li Pu Guofcng Jin Yuli JiXiaolin
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| Abstract: |
| Three groups of adult milk goats were orally administrated of different doses of sodium selenite weekly for seven week. The clinic signs of the experimental goats gradually were worsened.Pathological lesions were presented in cardiac-vessel,urinary,respiratory systems, etc.The serious extent of the pathological changes was in the orders of liver,kidneys,myocardium,spleen,lungs,lymph nodes,pancreas and brain. The principal pathological changes were denaturation,degeneration and necrosis in the tissue cells,deformation in the cell nucleus,decreasion in the chromatins,thinning out or vanishing in the ridge of mitochondrias and congestion,hemorrhage and edema in blood capillarys. It is showed that the affinity of different tissues to selenium is different,and the pathological changes of liver,kidneys ets. may be used as a reference basis in the diagnose of selenium intoxication in milk goats. |
| Key words: Milk Goat,Selenium,Selenium intoxication |
