| 摘要: |
| 【目的】结合《中国药典》(2005年版)规定指标及HPLC指纹图谱，对不同来源黄芪药材质量进行综合评价。【方法】测定来源于甘肃渭源、吉林舒兰、陕西凤县、甘肃陇西、山西浑源、陕西旬邑和陕西杨凌7个产区黄芪的总灰分、酸不溶性灰分、水溶性浸出物、醇溶性浸出物及黄芪甲苷的含量；建立黄芪药材样品的HPLC指纹图谱;对不同产地黄芪药材的质量指标和指纹图谱进行比较分析。【结果】不同产地黄芪样品的总灰分和水溶性浸出物均符合《中国药典》标准；醇溶性浸出物存在一定差异性；黄芪甲苷含量差异较大；不同样品HPLC指纹图谱共有15个共有峰，图谱间相似性较高。【结论】不同产地黄芪药材质量存在差异，多个指标综合评价能够更准确地反映黄芪药材的质量。 |
| 关键词: 黄芪 药材质量 HPLC指纹图谱 |
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| 基金项目:国家“十一五”科技支撑计划项目（2008BAD98B08）；农业部DUS测试品种信息（200903008-11） |
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| Quality diversity analysis of Radix Astragali from different habitats |
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| Abstract: |
| 【Objective】The study evaluated the quality of Radix Astragali collected from different habitats with a combination of Chinese Pharmcopoeia (Edition 2005) indexes and HPLC fingerprint method.【Method】The contents of total ash,acid insoluble ash,watery extract,ethanolic extract and contents of astragaloside IV of Radix Astragali from Weiyuan Gansu,Shulan Jilin,Fengxian Shaanxi,Longxi Gansu,Hunyuan Shanxi,Xunyi Shaanxi,Yangling Shaanxi were determined;the fingerprint of Radix Astragali from different habitats was established by HPLC methods;and the quality indexes and fingerprint were compared and analyzed.【Result】All contents of total ash and watery extract reached the pharmacopeia standards;some differences existed among ethanolic extracts of different samples;the contents of astragaloside IV had obvious difference among the different Radix Astragali;there were 15 common peaks in the HPLC fingerprints and the fingerprints had high similarity.【Conclusion】The quality of Radix Astragali from different habitats was different.Multi-indices to assess the quality of Radix Astragali could make assessment result more accurate. |
| Key words: Radix Astragali quality HPLC fingerprint |
