| 摘要: |
| 用不同剂量（0.5，2.0，4.0 g/kg）牛膝正丁醇萃取物给配对前的成年小鼠连续灌喂15 d，检测部分雄鼠精液品质、睾丸发育情况和内脏器官；同时在雌、雄小鼠合笼后观察小鼠妊娠及胚胎发育情况，以探讨牛膝正丁醇萃取物对成年小鼠繁殖性能的影响。结果表明。牛膝正丁醇萃取物不能明显干扰小鼠的繁殖性能，小鼠可以正常发情、妊娠，且胎儿发育正常，仅4.0 g/kg剂量处理组母鼠的胎仔数与其他各组相比差异显著（P<0.05）。2和4 g/kg灌喂剂量可引起小鼠脾脏、肝脏、肾脏出现急性炎症反应。 |
| 关键词: 牛膝正丁醇萃取物 小鼠 繁殖性能 内脏病变 |
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| 基金项目:西北农林科技大学青年科研专项（04zm023） |
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| Effects of n-Butanol extract from Achyranthes bidentata on reproductive performance of mice |
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| Abstract: |
| In order to study the reproductive effects of n-butanol extract from Achyranthes bidentata on premarital mice,the research observed-testis,sperm quality and viscera of male mice,as well as Pregnancy and fetuses of female mice after n-butanol extract from A.bidentata （0.5,2.0,4.0 g/kg） po for 15 d in premarital mice.The results showed that it had no significant antifertility action in females and males，except that viable fetuses per pregnant mouse in groupⅠ (4.0 g/kg) was significantly different from that of the control mice (P<0.05).Meanwhile,significant pathological changes were found in the liver,spleen and kidney in the n butanol extract of achyranthes bidentata supplementation when the dosage was 2.0 g/kg and 4.0 g/kg. |
| Key words: n-butanol extract from Achyranthes bidentata mice reproductive performance viscera |
