| 摘要: |
| 应用多聚酶链式反应对96例老年AS患者及92例非AS老年人HUMARA-STR位点进行多态性分析。结果表明:① 在HUMARA位点重复单位CAG,对照群体片段大小280～445 bp,重复次数为N=23～77,杂合度为83%，多态信息量为0.76。②AS人群中HUMARA位点片段大小220～445 bp，重复次数为N=2～77,杂合度为89%，多态信息量为0.80。③将男性的AS组与对照比较差异显著;AS组男性与女性比较差异显著。 |
| 关键词: HUMARA基因 动脉粥样硬化 遗传标记 |
| DOI： |
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| 基金项目:国家自然科学基金资助项目(39700165) |
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| Relationship between HUMARA polymorphism and atherosclerosis |
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| Abstract: |
| The ploymorphism at HUMARA-STR locus was studied by PCR in 96 cases of atheroclerosis and 92 cases of normal old people of Shaanxi.The result shows that:① Repeat base of HUMARA loci is CAG.Many Alleles ranging from 280 bp to 445 bp were revealed in normal old people of Shaanxi.The number of repeat base is range from 23 to 77.The heterozygosity of HUMARA was 83%,PIC 0.76;② Many Alleles ranging from 220 bp to 445 bp were revealed in AS.The number of repeat base is range from 2 to 77.The heterozygosity of HUMARA was 89%.PIC,0.80.③ There are obviously difference in distribution of allele frequency between male AS and male control.There are obviously differences in distribution of allele frequency between male AS and female AS. |
| Key words: HUMARA gene atherosclerosis genetic marker |
