| 摘要: |
| 对吡喹酮驱虫速溶片剂的辅料进行了初步筛选，采用正交试验法L8（27）探讨了最佳处方。结果表明，吡喹酮驱虫速溶片剂的最佳处方由羟丙基纤维素300 g/kg，微晶纤维素300 g/kg，淀粉400 g/kg和适量聚乙烯吡咯烷酮（质量分数为1％）等辅料组成。用紫外分光光度法进行含量测定。结果表明平均回收率为99.53%，有效成分含量按标示量计平均值为97.42%，相对标准差分别为0.96%和0.59%。质量检测结果表明，吡喹酮的平均片重为0.503 2 g，重量差异3.2%，已达到《中华人民共和国药典（2000年版）》要求。 |
| 关键词: 驱虫兽药 吡喹酮 速溶片剂 |
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| Preparative studies on anthelmintic praziquantel fast dissovling tablets |
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| Abstract: |
| Adjuvants have been screened about praziquantel fast dissovling tablets.The preferable for mulation has been choosed according to orthogonal experiment design L8（27）.The preferable formulation consists adjuvants such as hydroxypropyl cellulose (mass number was 300 g/kg),microcrystalline cellulose (mass number was 300 g/kg),strch (mass number was 400 g/kg) and palyvidone (mass fraction was 1%).The content of praziquantel has been determined by ultraviolet spectrophotometry.Mean recovery rate is 99.53% respectively.The results of qualities test are that mean weight of tablet is 0.503 2 g and weight difference is 3.2%.It accords with “Pharmacopoeia of the People’s Republic of China”. |
| Key words: anthelmintic praziquantel fast dissovling tablets |
