| 摘要: |
| 用醇提取和溶剂分离法从瑞香狼毒根中提得瑞香狼毒总黄酮进行动物毒性试验.结果表明,小白鼠灌胃LD50为524.81mg/kg,家兔耳静脉注射75mg/g后主要表现角弓反张.痉挛抽搐.呼吸困难,心电图显示心力衰竭印象.麻醉家兔耳静脉注射25mg/kg后出现呼吸、脉搏减慢及短哲的脉压增大,随后脉压消失;家兔灌胃700mg/kg后出现腹痛、腹泻和体温下降.血清GPT、GOT、AKP活性24h内无变化,而BUN含全显著升高,病理变化以各脏器寮血、胃肠道出血、肺气肿及心肌纤维、肝细胞和肾小管上皮细胞颖粒变性为特性.对家兔离体肠道运动有抑制,皮肤原发刺激指数为2.89,属中等刺激物. |
| 关键词: 瑞香狼毒，总黄酮，小白鼠，家兔，毒性 |
| DOI： |
| 分类号:S856.9 |
| 基金项目: |
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| abstraction and Toxkity of Total-Flavonoid in Stellera chamaejasme L |
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Song Xiaoping Cao Guangrong Li Shaojun
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| Abstract: |
| Total-flavonoid with flavonoid compound content of 22.72% was obtained from the roots of S chamaejasme L.by means of ethanol extraction and solvent process.The total-flavonoid toxicity experiments indicated that the LD50 in mice given orally was 524.81 mg/kg,rabbits poisoned by intravenous injection at dosage of 75 mg/kg showed the symptoms of opisthotonus,spasm,dyspnea,and heart failtire in ECG;the anesthetized rabbits given by inter-venous injection at the dosage of 25 mg/kg showed the symptoms of reduced respiratory and pulse rate,transiently increased pulse pressure and then disappearance;rabbits given orally at the dosage of 700 mg/kg showed the symptoms of abdominal pain,diarrhea,and body temperature decline;the activities of serum GPT,GOT,AKP had no change,but concentration of BUN elevated signifiently in 24 h;pathological finding characterised by intensive extravasation of viscera,gastroenteric heamorrhage,pneumonectasis and the granular degeneration of hepatocytes,epithelial cells of renal tubules and cardiac muscle,the automatic contraction of extracorporeal small intestine of rabbits could be inhibited,primary stimulative of skin was 2.89,belonging to a middle stimulant. |
| Key words: Stellera chamaejasme L.,total-flavonoid,mice,rabbit,toxicity |
