| 摘要: |
| 【目的】研究磺胺噻唑在山羊体内的药物动力学过程，为该药在兽医临床的合理应用提供依据。【方法】用磺胺噻唑对照品配制标准溶液，建立磺胺噻唑的紫外测定方法。给6只山羊分别静脉注射剂量为70 mg/kg的磺胺噻唑钠，于注射前和注射后5，10，15，30，45，60，120，180，240和300 min分别颈静脉采血，测定血药质量浓度，用残数法拟合药 时曲线，计算其药物动力学参数。【结果】磺胺噻唑在山羊体内的药物动力学符合二室模型。药物动力参数消除相初始质量浓度B为(198.37±64.63) mg/L，分布相半衰期t1/2α为(0.05±0.04) h，消除相半衰期t1/2β为(0.89±0.21) h，表观分布容积Vd为(0.15±0.07) L/kg，体内消除率CL(s)为(0.28±0.08) mg/(kg·h)，有效血药浓度维持时间为(1.58±0.58) h。【结论】磺胺噻唑在山羊体内为短效药物。 |
| 关键词: 磺胺噻唑 山羊 药物动力学 |
| DOI： |
| 分类号: |
| 基金项目:西北农林科技大学大学生科技创新项目（2201310712034） |
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| Pharmacokinetics of sulfathiazole in goats |
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ZHAI Xin-gui,ZHANG You-liang,ZHAO Biao,et al
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| Abstract: |
| 【Objective】Pharmacokinetics of sulfathiazole(ST) in goats was studied to provide the basis for its rational application in veterinary clinical.【Method】ST reference substance was used to prepare standard solution and a UV measurement method was established.ST was given to 6 goats intravenously at a dose of 70 mg/kg of ST-Na.Blood samples were taken from jugular vein before injection and 5,10,15,30,45,60,120,180,240 and 300 min after injection.Then concentrations of ST in serum were determined and concentration-time relationship was fitted by residual method to calculate the pharmacokinetic parameters of ST in goats.【Result】The two-compartment open model was suitable to describe the pharmacokinetics of ST in goats.Pharmacokinetic parameters were:initial concentration (198.37±64.63) mg/L,t1/2α (0.05±0.04) h,t1/2β (0.89±0.21) h,Vd (0.15±0.07) L/kg,CL(s) (0.28±0.08) mg/(kg·h),and tcp (1.58±0.58) h.【Conclusion】ST was proved to be a short acting medication to goats. |
| Key words: sulfathiazole(ST) goats pharmacokinetics |
