| 摘要: |
| 【目的】研究干酪乳杆菌与银杏叶提取物协同的降血脂及抗氧化作用。【方法】将体质量为（20±1.0） g/只的60只健康雌性小鼠随机分成5组，即空白对照组、高脂对照组、干酪乳杆菌组、银杏叶提取物组及干酪乳杆菌与银杏叶提取物混合组，除空白对照组外，其余4组均给予高脂饲料，建立肥胖模型，试验期为30 d。试验结束后测定各组小鼠体质量，血清中的总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白胆固醇（HDL-C）、丙二醛(MDA)浓度及谷胱甘肽过氧化物酶(GSH-Px)和过氧化氢酶（CAT）等的活性。【结果】干酪乳杆菌与银杏叶提取物协同作用，能明显降低肥胖小鼠体质量、TC、TG和MDA，与高脂对照组相比，小鼠体质量降低13.22％，TC和TG降解率分别达到24.48％和20.93％，差异极显著(P＜0.01)；小鼠血清中HDL-C增加167.85％，差异极显著(P＜0.01)；小鼠血清中GSH-Px活性提高了13.14％(P＜0.05)，CAT活性降低了49.01％(P＜0.01)。【结论】干酪乳杆菌与银杏叶提取物协同使用，具有控制小鼠体质量、降血脂、促进胆固醇代谢的作用，可用于预防和治疗高脂血症。 |
| 关键词: 干酪乳杆菌 银杏叶提取物 降血脂 抗氧化 |
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| 基金项目:教育部留学回国人员科研启动基金项目(200835-1)；四川省学术带头人培养基金项目 |
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| Effects of Lactobacillus casei and Ginkgo biloba extract on blood lipids and anti－oxidation of obese mice |
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WEN Xiao,HE Da-fang,NI Xue-qin,et al
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| Abstract: |
| 【Objective】The purpose of this experiment was to study the synergistic effects of Lactobacillus casei and Ginkgo biloba extract synergies on lowering blood lipids and anti-oxidation.【Method】60 mice were randomly divided into five groups:blank control group,high-fat control group,L.casei group,G.biloba extract group,and L.casei and G.biloba extract mixture group.High fat diet was fed to groups except blank control to establish obesity model with a period of 30 days.Body weight,serum total cholesterol (TC),triglyceride (TG),high density lipoprotein cholesterol (HDL-C),content of malondialdehyde (MDA),and activities of glutathione peroxidase (GSH-Px) and catalase (CAT) were detected.【Result】 Compared with high-fat control group,L.casei and G.biloba extract significantly reduced body weight,TC,TG and MDA by 13.22%,24.48%,20.93% and 5.98%,respectively (P＜0.01).The mouse serum HDL-C was enhanced by 167.85% (P＜0.01).The activity of GSH-Px was increased by 13.14% (P＜0.05),and the activity of CAT was decreased by 49.01% (P＜0.01).【Conclusion】Synergistic taking of L.casei and G.biloba extract synergies could control body weight,lower blood fat,promote cholesterol metabolism,and prevent and treat hyperlipidemia. |
| Key words: Lactobacillus casei Ginkgo biloba extract lowering blood fat anti oxidation |
