| 摘要: |
| 【目的】探讨桂皮提取物对糖尿病大鼠血糖和血脂含量的影响。【方法】给大鼠腹腔注射200 mg/kg的四氧嘧啶建立糖尿病模型。试验共分4组：正常对照组(Ⅰ)、糖尿病模型组(Ⅱ)、低剂量桂皮提取物组(Ⅲ)和高剂量桂皮提取物组(Ⅳ)，Ⅲ、Ⅳ组糖尿病模型大鼠分别灌服100和200 mg/(kg·d)的桂皮提取物，连续灌服30 d；Ⅰ、Ⅱ组大鼠分别灌服生理盐水，方法和剂量同前。试验期间观测各组大鼠饮食、尿量，并在0 d(开始时)和30 d时， 取样测定大鼠血糖、血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL C)水平和体质量。【结果】试验开始时，与Ⅰ组相比，Ⅱ、Ⅲ和Ⅳ组大鼠体质量显著降低(P＜0.05)，血糖显著提高(P＜0.05)。试验结束时，与Ⅱ组相比，Ⅳ组大鼠血糖及血清TC、TG和LDL C水平显著降低(P＜0.05)，而体质量和HDL-C水平显著升高(P＜0.05)；而Ⅳ组与Ⅰ组相比，大鼠体质量、血糖及血清TC、TG、LDL-C和HDL-C水平差异均不显著(P＞0.05)。【结论】灌服200 mg/(kg·d)的桂皮提取物，能够降低四氧嘧啶所致糖尿病大鼠的血糖及血清TC、TG和LDL-C水平，增加其体质量，提高其血清HDL-C水平。 |
| 关键词: 桂皮 四氧嘧啶 糖尿病大鼠 血糖 血脂 |
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| 基金项目:山东省教育厅科技计划项目(J07WF03) |
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| Effects of cinnamon on blood sugar and lipid levels in diabetic rats |
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| Abstract: |
| 【Objective】The study was conducted on the effects of cinnamon on blood sugar and lipid levels in diabetic rats.【Method】The diabetic rats were induced by intraperitoneal injection of 200 mg/kg alloxan to establish diabetic model.The rats were divided into control group (Ⅰ),model group (Ⅱ),low dose cinnamon treating group (Ⅲ) and high dose cinnamon treating group (Ⅳ).The diabetic rats of group Ⅲ and Ⅳ were orally administered with 100 and 200 mg/(kg·d) cinnamon extract respectively,for 30 days.The rats of group Ⅰ and Ⅱ were orally administered with saline respectively by the same way and the same dose.The daily feed consume,water intake and urine excretion were recorded.The blood sugar,TC,TG,LDL-C,HDL-C level and the body weight were estimated at 0 and 30 d.【Result】Compared with the rats of group Ⅰ,the body weight of all the diabetic rats of group (Ⅱ,Ⅲ and Ⅳ) decreased significantly (P<0.05),and the blood sugar level increased significantly (P<0.05) at 0 d.Compared with the rats of groupⅡ,the blood sugar,TC,TG,LDL-C level of the diabetic rats in group Ⅳdecreased significantly (P<0.05),the body weight and HDL-C level increased significantly (P<0.05) at 30 d.Compared with the rats of group Ⅰ,there were no differences in body weight,blood sugar,TC,TG,LDL-C and HDL-C level of the diabetic rats in group Ⅳ at 30 d (P>0.05).【Conclusion】The cinnamon extract (200 mg/(kg·d)) decreased the blood sugar,TC,TG and LDL-C level of the diabetic rats induced by alloxan,increased the body weight and enhanced HDL-C level.Enrichment of cinnamon with cinnamate can provide a functional food spice that could potentially benefit human health. |
| Key words: cinnamon alloxan diabetic rat blood sugar lipid |
