| 摘要: |
| 【目的】 探讨玉米幼芽提取物对乳腺增生SD大鼠乳腺组织和血清激素的影响，及其抗乳腺增生的作用机理。【方法】 以苯甲酸雌二醇联合黄体酮皮下注射方法，制作乳腺增生大鼠模型56只，随机平均分成7组。将玉米幼芽提取物按剂量0，1.25，2.5，5，10，20,40 mg/(kg·d)分别给药，连续20 d，用药结束后测定大鼠血清激素水平；显微镜下观察大鼠乳腺组织。【结果】 玉米幼芽提取物中，高剂量组明显改善了病变组织的形态，并且可显著降低模型大鼠的卵泡生成素（FSH）、血清雌二醇（E2）和睾酮(T)水平，同时提高了模型大鼠催乳素（PRL）和血清黄体生成素（LH）水平，对血清孕酮(P)变化的影响不大。【结论】2.5～40 mg/(kg·d)的富含腺嘌呤类衍生物的玉米幼芽提取物，可有效防止和治疗大鼠的乳腺增生。 |
| 关键词: 玉米幼芽提取物 乳腺增生 氧化损伤 大鼠 |
| DOI： |
| 分类号: |
| 基金项目:国家科技支撑计划项目(2006BAD04A11) |
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| Effect of extracts of maize plumule on mammary gland hyperplasia rats |
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SUN Ying1 WANG De xiang1 ZHANG Hao2 LI Zhi gang3 WEI Yao feng2 HU Tian hua3
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| Abstract: |
| 【Objective】 The study was to observe the effects of extracts of maize plumule given in different doses on mammary gland hyperplasia of rats and explore the mechanism for the treatment of mammary gland hyperplasia.【Method】 8 healthy rats were set as normal contrast groupⅠ.56 model rats were divided into 7 groups(groupⅡ-groupⅧ),and the model of mammary gland hyperplasia was made by hypodermic injection of oestradiol benzoate and progesterone.Model groups(Ⅱ-Ⅷ) were intragastrically administered with 0,1.25， 2.5， 5， 10， 20， 40 mg/(kg·d) gradient doses maize plumule extracts.Then the length and diameter of nipples were measured,and the sex hormone of all groups checked.And the slides of mammary glands were observed by microscopic examination.【Result】 After drugs interference,medium dose groups and high dose groups(Ⅴ-Ⅷ) showed the mend of the mammary glands shapes and pathological tissue in vivo(P<0.01）);Extracts of maize plumule remarkably depressed the level of FSH,E2 and T,and raised the level of PRL and LH(P<0.01) inⅤ-Ⅷ groups,but P was steady.【Conclusion】 2.5-40 mg/（kg·d）maize plumule extracts with abundant adenine derivatives conld effectively prevent and treat hyperplasia of mammary gland. |
| Key words: extracts of maize plumule hyperplasia of mammary gland oxidative damage rat |
