| 摘要: |
| [目的]研究丁香酚微囊的制备工艺,并对所制备的微囊质量进行评价.[方法]以海藻酸钠为囊材、丁香酚为囊心、吐温-80为乳化剂制备丁香酚微囊,用正交试验优化制备工艺,对微囊的形态、药物包封率及其挥发性进行检测.[结果]丁香酚微囊的最佳制备工艺条件为:海藻酸钠质量浓度为25 g/L,海藻酸钠与丁香酚质量比为1∶1,吐温-80添加量为0.3%.按以上工艺所制备的丁香酚微囊呈圆球形,表面光滑,粒径为35～65 μm的丁香酚微囊占76.1%～78.4%,丁香酚含量为820.7～823.5 mg/g,包封率为87.5%～87.8%.100 ℃加热后10 h,微囊中丁香酚的挥发率为13.4%,而原料药丁香酚的挥发率为42.4%(P<0.01).[结论]确定了丁香酚微囊的最佳制备工艺条件,所制备的微囊圆整光滑,包封率高,稳定性好. |
| 关键词: 海藻酸钠 丁香酚 微囊 制备工艺 凝聚法 |
| DOI： |
| 分类号: |
| 基金项目:国家自然科学基金 |
|
| Studies on preparation and quality evaluation of eugenol miscrocapsules |
|
|
| Abstract: |
| 【Objective】 The research was to study the preparation conditions of eugenol microcapsules and their quality evaluation.【Method】 The eugenol miscrocapsules were made by using sodium alginate as wall material,eugenol as core and Tween-80 as emulsifier,and the process was optimized by orthogonal experiment,as well as the formulation,drug encapsulation efficiency and volatile of microcapsules were investigated.【Result】 The optimum parameters were that the concentration of sodium alginate was 25 g/L,the weight ratio of sodium alginate to eugenol 1∶1,the proportion of Tween-80 0.3%,and the prepared microcapsules spherical with smooth surface,and the proportion with a diameter of 33-65 μm 76.1%-78.4%.The content and encapsulation efficiency of eugenol was 820.7-823.5 mg/g and 87.5%-87.8% respectively.The voltile rate of eugenol in the microcapsules was 13.4%,and that of the material eugenol 42.4%（P<0.01）after heating 10 h at 100 ℃.【Conclusion】 The optimal conditions were confirmed.The eugenol microcapsules were spherical with smooth surface, high encapsulation efficiency and good stability. |
| Key words: sodium alginate eugenol microcapsule preparation technology coacervation method |
