摘要: |
分别采用差示扫描量热法(DSC)、热重法(TG)和微分热重法(DTG),研究了喹诺酮类(吡哌酸、诺氟沙星)抗菌药的热分解动力学过程,计算了其热分解动力学参数——活化能(E),分析了其热分解机理,并剖析了喹诺酮类药物有机结构上的差异。 |
关键词: 差示扫描量热法(DSC) 热重法(TG) 微分热重法(DTG) 热分解特性 吡哌酸 诺氟沙星 |
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基金项目:陕西理工学院重点学科分析化学建设项目(2000);陕西理工学院重点课程有机化学建设项目(2002) |
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Studies on the thermal decomposition characteristics of Quinolone drugs of Pipemidic Acid and Norfloxacin |
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Abstract: |
The thermal characteristics of Quinolone drugs of Pipemidic Acid and Norfloxacin were analyzed by DSC (differentia scanning calorimetry),TG (thermogravimetry),DTG (differential thermogravimetry).The thermal kinetic parameter-energy of activation (E) was calculated as well.The thermal decomposition characteristics and the difference of Quinolone drugs in organic structure were analyed as well. |
Key words: DSC TG DTG thermal decomposition characteristics Pipemidic Acid Norfloxacin |