| 摘要: |
| 哺乳动物胚胎干细胞一般可从胚胎囊胚内细胞团分离得到，具有在体外保持不分化的无限增殖能力，在合适的培养条件下，胚胎干细胞可定向诱导分化形成多种细胞类型。人们对胚胎于细胞进行体外培养与定向分化可以得到大量同源细胞，以应用于患疾病的细胞或器官移植治疗等研究。文章概述了胚胎干细胞增殖与分化的信号调节机制、诱导分化方法，国内外研究概况及展望4个方面的内容。 |
| 关键词: 胚胎干细胞 诱导分化 信号调节机制 |
| DOI： |
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| 基金项目:国家重点基础研究发展规划基金资助项目(G1999054301-5) |
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| Research progress on induced differentiation of embryonic stem cells |
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| Abstract: |
| Embryonic stem cells were derived from the inner cell masses of cultured blastocysts in mammal and capable of unlimited,undifferentiated proliferation in vitro.At the same time,embryonic stem cells could also be directly induced to differentiate in culture into a variety of cell types under appropriate conditions.Homogeneous populations of cells produced by directed differentiation in vitro could be applied to study the cell replacement therapies of disease,etc.This paper elaborated signaling mechanisms regulating self-renewal and differentiation on induced differentiation of embryonic stem cells,methods of induced differentiation of embryonic stem cells,research progress and prospects on induced differentiation of embryonic stem cells. |
| Key words: embryonic stem cells induced differentiation signaling mechanisms |
