| 摘要: |
| 以苯胺为原料，通过氨基保护、酰基化、去氨基保护、苯环上双氯代、溴代、胺取代和还原等7个单元反应合成了β－兴奋剂－－“克仑特罗”。并对部分重要中间体和目标物，通过熔点测定、Beilstein试验、紫外光谱（UV）、红外光谱（IR）、质谱（MS）进行了结构鉴定，对部分单元反应的条件进行了研究和讨论，为其类似物的合成提供了一定的理论参考和实践依据。 |
| 关键词: β-兴奋剂 克仑特罗 合成 苯胺 |
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| Research on synthesis of β-adrenergic agonists (Clenteral) |
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| Abstract: |
| In this research,aniline is used as raw material,and seven unit reactions such as protecting amino groups,acetylation,chopping off protection of amino groups,disub-chlorination on benzene ring,chlorination,bromination,replacing of amine and reduction etc are conducted to successfully synthesize β-adrenergic agonists-“Clenteral”.The Structures of some important intermedia and objective substance are identified through the following methods-assay of melting point,Beilstein testing,ultraviolet spectrum(UV),infrared spectrum(IR),mass spectrum (MS).Some reaction conditions are studied and discussed,Some reference are provided theoretically and practically for synthesizing similar substance. |
| Key words: β-adrenergic agonists Clenteral synthesis aniline |
