| 摘要: |
| 用溴乙酸制备的活性酯与苦马豆素反庆，产物真空干燥后得到白色粉末状物，产率为77％。经MP、IR鉴定和元素分析的结果判定，白色粉末状物为苦马豆素-活性酯结合的季铵盐。季铵盐再与BSA反应，产物经透析、冻干后呈白色针状结晶，按BSA计算，产率为91％，经测定，平均每个BSA分子上结合了18.17个季铵盐分子。 |
| 关键词: 苦马豆素 BSA 活性酯 季铵盐 |
| DOI： |
| 分类号: |
| 基金项目:国际科学基金资助项目(IFS,No.2906-1);国家自然科学基金资助项目(39770571) |
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| Study on synthesis of swainsonine-BSA |
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| Abstract: |
| In this study the swainsonine was synthesized with active ester,which was prepared by 2-bromine-acetic acid,to obtain white powder.The yield was 77%.The white powder was quaternary salt of swainsonine-ester identified by MP,IR and element analysis.The quaternary salt was synthesized with BSA,dialysed and lyophilized the production to obtain crystal of white needle.The yield was 91%,according to BSA.Each BSA molecule has combined 18.17 molecules of quaternary salt after determination. |
| Key words: swainsonine SA active ester quaternary salt |
