| 摘要: |
| 用一个新的氨基醇(1R, 2S)-2-氨基-3-甲基-1-(2, 5-二甲基苯基)-1-丁醇为手性配体,硼烷为还原剂,研究了2, 2′, 4′-三氯苯乙酮和2-咪唑基-2′, 4′-二氯苯乙酮的对映选择还原。并讨论了催化剂用量、温度对还原效果的影响。 |
| 关键词: 手性氨基醇，硼烷，对映选择还原 |
| DOI： |
| 分类号:O62 |
| 基金项目: |
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| A New Chiral Amino Alcohol used in the Enantioselective Reduction of Ketones |
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| Abstract: |
| A new amino alcohol (1R, 2S)-2-amino-3-methyl-1-(2, 5-dimethyl
phenyl)-1-butanol, as a chiral ligand, was used in the enantioselective reduction of 2,
2′, 4′-trichloroacetophenone and 2-imidazol-2′, 4′-dichloroacetophenone. The effect of
the amount of catalyst and reaction temperature on enantioselectivity of the reduction
were discussed. |
| Key words: chiral amino alcohol,borane,enantioselective reduction |
