| 摘要: |
| 由肌苷开始经五步合成出N6－（6－氮基己基）－5’－磷酸腺苷。对6－氯－9-β－D－呋喃核糖嘌呤的合成进行了改进。1，6－己二胺同6－氯－9-β－D呋喃核糖嘌呤－5’－磷酸发生取代反应，合成出N6－（6－氮基己基）－5'－磷酸腺苷，基于核苷的总产率约70%。 |
| 关键词: 肌苷，核苷，5′－单磷酸腺苷，酶免疫测定，亲和层析 |
| DOI： |
| 分类号:O629 |
| 基金项目:高等学校博士点基金和杨陵基金资助项目 |
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| Synthesis of N6-(6-aminohexyl)-adenosine-5'-Phosphoric acid |
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| Abstract: |
| N6-(6-aminohexyl)-adenosine-5’-Phosphoric acid was obtained from inosine
via five steps.An improved synthesis of 6-chloro-9-β-D-ribofuranosylpurine was reported.
from 6-chloro-9-β-D-ribofuranosylpurine-5'-phosphoric acid,N6-(6-aminohexyl)-adenosine
5'-phosphoric acid was synthesized by a process involving substitution of the 6-chloro-group
by l,6-diaminohexane giving about 70% overal yield from nucleoside. |
| Key words: inosine,nucleside,adenosine-5'-phosphoric acid,enzyme immunoassay,affinity chromatography |
