| 摘要: |
| 测定了8只健康奶山羊和其功能性肾组织减少75％时的肾清除率以及快速静注SM2的药代动力学参数。结果表明,后者肾功能比正常平均减小约66％;药-时曲线从C正常=5.5e-6.5376t+24.29e-0.2162t改变为C肾功减退=6.78e-4.958t+23.02e-0.1425t.其他动力学参数与健康时比较t1/2β延长了75％;AUC增加了49％;tCP(ther)延长了52％,但β和Clβ显著降低(P<0.01)。多次静注的药动学研究表明,其血药浓度同单剂量推算的结果没有差异。 |
| 关键词: 磺胺二甲嘧啶,药代动力学,肾功能减退,奶山羊 |
| DOI： |
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| Pharmacokinetics of Sulfadimidum (SM2) in Milk Goats with Experimental Reduced Renal Functions |
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Cao Guangrong Hu Wenjie Li Shaojun Xi Peng Li Zhuye Qiang Zhenjuan
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| Abstract: |
| The rena1 clearance and the parameters of pharacokinetics of Sulfadimidinew ere determined in 8 milk goats with their renals in norma1 functions．and then 75％ of reduction in reana1 functions were determined by giving fast intravenous in jiections of SM2．The results indicated that the mean reduction in rena1 functions of the 1atter was approximately 66％ 1ower than that in normal ones．The blood concentration time equations of the drug varied from Cnormal=5.5e-6.5376t+24.29e-0.2162t to C
reduced=6.78e-4.958t+23.02e-0.1425t.In comparison of other parameters of pharama-cokinetics in milk goats with reduced rena1 functions with those in health milk goats，t1/2β prolonged 75％；AUC increased by 49％；tcp(ther)prolonged 52％；but β and Clβ decreased significantly(P<0.01)．Also，the studies of multiple intravenous injections of pharacokinetics of SM2 indicated that there was no difference between the blood concentration of SM2，and the deduced results with single dosage． |
| Key words: Sulfadimidium, pharmacokinetics, reduced renal function, milk goat |
