| 摘要: |
| 给七只成年健康奶山羊单剂量快速静注 TMP(10mg/kg)后,六小时内不同时间采血,用反相高效液相色谱(RP—HPLC)法测定血清 TMP 浓度,以残量法拟合药一时曲线得最佳方程为:C=11.64e-5.4039t+1.47e-0.757t.其它动力学参数如下:Co:13.11±2.68μg/ml;t?α:0.15±0.06h;t?β:0.94±0.19h;Vd:3.4921±1.3285L/kg;AUC:4.29±1.35h·μg/ml;K12:1.6581±1.2942h-1;k21:1.2276±0.3234h-1;k10:3.2761±0.8732h-1;Cl:2.5328±0.7768L/kg;tcp(ther):2.33h. |
| 关键词: 甲氧苄胺嘧啶,药代动力学,奶山羊,高效液相色谱 |
| DOI： |
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| PHARMACOKINETIC STUDY OF TRIMETHOPRIM(TMP) IN MILK GOATS |
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Hu Wenjie Liu Qingyu Wang Jianyuan Li Fu'e Li Tianrong Li Lianchao,Hu Wenjie Liu Qingyu Wang Jianyuan Li Fu'e Li Tianrong Li Lianchao,Hu Wenjie Liu Qingyu Wang Jianyuan Li Fu'e Li Tianrong Li Lianchao
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| Abstract: |
| Pharmcokinetics(pk) of distribution and elimination of TMP in seven normal adult milk goats was reported.TMP was administrated intravenously by a single dose,10mg/kg of their body weight.Blood samples were collected at the diffrent time within 6 hours after the drug was given.The concentrations of TMP in the serum samples were determined by the RP-HPLC method.The serum concentration-time curves of the drug fitted a two-compartment open model: C=11.64e-5.4039t+1.47e-0.757t.The other parameter valuesof PK in milk goats are described as follow:Co:13.11±2.68μg/ml;t?α:0.15±0.06h; t?β:0.94±0.19h;Vd:3.4921±1.3285L/kg;V1:0.7891±0.1511/kg; AUC:4.29±1.35h·μg/ml;K12:1.6581±1.2942h-1; k21:1.2276±0.3234h-1;k10:3.2761±0.8732h-1; Cl:2.5328±0.7768L/kg;tcp(ther):2.33h. The results showed that TMP is a kind of short-action drug for milk goats. |
| Key words: TMP,pharmacokinetics,milk goat,RP-HPLC,Trimethoprim |
