| 摘要: |
| 氨基酸不仅是胶原蛋白合成的底物，而且可以作为信号分子参与胶原蛋白代谢的调控。文章从胶原蛋白合成和分解代谢角度对胶原蛋白代谢的营养调控研究进行综述，重点梳理了甘氨酸（glycine，Gly）、脯氨酸（proline，Pro）和羟脯氨酸（hydroxyproline，Hyp）对胶原蛋白代谢的影响，及其介导胶原蛋白代谢的潜在信号通路和分子机制，并对未来的研究方向进行了展望。 |
| 关键词: 胶原蛋白 代谢途径 甘氨酸 脯氨酸 羟脯氨酸 |
| DOI： |
| 分类号: |
| 基金项目:云南省农业基础研究联合专项(2017FG001-021,2018FG001-044)；长江上游鱼类资源保护与利用四川省重点实验室开放基金项目(NJTCCJSYSYS12)；四川省科技厅重点研发项目(2019ZYZF0099) |
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| Research progress of glycine,proline and hydroxyproline mediated collagen metabolism |
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RONG Hua,WANG Zhengyang,HAO Tingting,et al
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| Abstract: |
| Amino acids are not only substrates of collagen synthesis,but also signal molecules to participate in regulation of collagen metabolism.In this paper,we reviewed the nutritional regulation of collagen metabolism from collagen synthesis and catabolism.The effects of glycine (Gly),proline (Pro) and hydroxyproline (Hyp) on collagen metabolism,as well as the potential signaling pathways and molecular mechanisms involved in mediating collagen metabolism were summarized. Future research directions were also forecasted. |
| Key words: collagen metabolic pathways glycine (Gly) proline (Pro) hydroxyproline (Hyp) |
