| 摘要: |
| 【目的】比较氟苯尼考及其磷脂复合物在大鼠小肠中的吸收情况。【方法】采用平衡法测定氟苯尼考及其磷脂复合物的溶解度和脂水分配系数，采用离体外翻肠囊法研究氟苯尼考及其磷脂复合物在大鼠不同肠段的吸收情况，同时采用单向在体肠灌流法重点考察氟苯尼考及其磷脂复合物在大鼠十二指肠的吸收差异。【结果】氟苯尼考磷脂复合物较氟苯尼考原药的溶解度提高了36.14%，脂水分配系数降低了47.62%，且在大鼠小肠各段的促进吸收率大小表现为十二指肠＞回肠＞空肠。氟苯尼考磷脂复合物在十二指肠的表观吸收系数(Papp)、有效渗透系数(Peff)和吸收速率常数(Ka)较氟苯尼考原药分别增加了121.93%，109.48%和90.83%。【结论】氟苯尼考磷脂复合物可以促进氟苯尼考在大鼠小肠中的吸收。 |
| 关键词: 氟苯尼考 磷脂复合物 离体外翻肠囊法 在体肠灌流法 |
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| 基金项目:四川农业大学优秀硕士论文培育基金项目（YS2014005） |
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| Absorption differences between florfenicol and its phospholipid complex in small intestinal of rats |
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FAN Guoqing,LIU Mengjiao,FU Hualin,et al
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| Abstract: |
| 【Objective】This study compared the absorption of florfenicol and its phospholipid complex in small intestine of rats. 【Method】The solubility and lipid water partition coefficient of florfenicol and its phospholipid complex were measured using the balance method.The everted gut sac method was adopted to investigate the absorption of florfenicol and its phospholipid in different intestines of rats.One way intestinal perfusion model was also applied to investigate the absorption differences between florfenicol and its phospholipid complex in duodenum. 【Result】Compared with florfenicol,the solubility of florfenicol phospholipid complex was increased by 36.14% and its lipid water partition coefficient was reduced by 47.62%.The promote absorption rates in rat small intestine were in the order of duodenum >ileum>jejunum.The apparent absorption coefficient (Papp),effective permeability coefficient (Peff) and absorption rate constant (Ka) in duodenum of florfenicol phospholipid complex were increased by 121.93%,109.48%,and 90.83%,respectively. 【Conclusion】Florfenicol phospholipid complex promoted the florfenicol absorption in small intestine of rats. |
| Key words: florfenicol phospholipid complex everted gut sac one-way intestinal perfusion model |
