| 摘要: |
| 动物基因组学研究是进行动物遗传资源保护和利用以及分子育种的一项重要基础工作，高通量测序技术的出现为动物基因组学研究带来了革命性飞跃。文章对基于高通量测序技术的动物基因组从头测序、重测序、简化基因组测序等基因组学研究进行了综述，总结了相关的生物信息分析内容，并对不同分析工具及方法进行了比较分析。最后，讨论了当前高通量测序技术存在的问题，对该技术未来发展方向进行了展望。 |
| 关键词: 高通量测序 动物基因组 数据处理 |
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| 基金项目:“十二五”国家863计划项目（2013AA102505，2011AA100307-02）；国家自然科学基金项目（31272411）；“十二五”国家科技支撑计划项目（2011BAD28B04-03）；“十二五”国家转基因育种重大专项（2013ZX08007-002）；国家肉牛牦牛产业技术体系建设专项（CARS-38） |
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| Research progress on animal genome research based on high-throughput sequencing technology |
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MEI Chu-gang,WANG Hong-cheng,ZAN Lin-sen,et al
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| Abstract: |
| Animal genomics research is important foundational work for protection,utilization,and molecular breeding of animal genetic resources.The emergence of high-throughput sequencing technology has brought revolutionary leap for animal genomics research.In this paper,we review the development of animal genomics research base on high-throughput sequencing technology,including whole genome de novo sequencing,whole genome re-sequencing,reduced representation genome sequencing (RRGS),and other areas of the genomics research work. We also summarize the main bioinformatics analysis content and compare different tools of data processing.Finally,the disadvantages and development prospects of high-throughput sequencing technology were discussed. |
| Key words: high-throughput sequencing animal genome data processing |
