| 摘要: |
| 【目的】研究复方阿莫西林舒巴坦钠纳米乳的制备方法，对其理化性质进行评价。【方法】以伪三元相图乳区面积大小为评定标准，确定复方阿莫西林舒巴坦钠纳米乳体系中各组分，考察阿莫西林与舒巴坦钠质量比不同时，所制备的复方阿莫西林舒巴坦钠纳米乳对奶牛乳房炎常见致病菌（金黄色葡萄球菌、大肠杆菌、无乳链球菌）抑菌效果，确定阿莫西林与舒巴坦钠的最佳质量比。最后对最佳配方下制备的复方阿莫西林舒巴坦钠纳米乳理化性质进行了分析。【结果】筛选出复方阿莫西林舒巴坦钠纳米乳配方是：阿莫西林1%，舒巴坦纳0.5% ，肉桂醛2.5%，PEG400为6.25%，RH-40为18.75%，蒸馏水为71%（以上均为质量分数）。阿莫西林与舒巴坦钠的最佳质量比为2∶1。制备的复方阿莫西林舒巴坦钠纳米乳为球形，其粒径大小为13.41 nm，多分散系数（PDI）为0.188，物理稳定性良好。【结论】成功研制出了复方阿莫西林舒巴坦钠纳米乳。 |
| 关键词: 阿莫西林 舒巴坦钠 纳米乳 伪三元相图 |
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| 基金项目:陕西省重大科技创新专项基金项目（k332020916） |
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| Preparation of compound nanoemulsion of amoxicillin and sulbactam sodium |
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WU Xiao-li,OUYANG Wu-qing,TANG Jia-xin
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| Abstract: |
| 【Objective】This study investigated the preparation of moxicillin and sulbactam sodiuma nanoemulsion and evaluated its physical and chemical properties.【Method】Nanoemulsion was prepared by the pseudo ternary phase diagram method.In vitro antibacterial activities of nanoemulsions with different ratios of amoxicillin to sulbactam sodium against common pathogenic bacteria of cow mastitis (Staphylococcus aureus,Escherichia coli,and Streptococcus agalactiae) were compared.The optimal ratio of amoxicillin to sulbactam sodiuma was then determined and the physicochemical properties of nanoemulsion with the optimal ratio were analyzed.【Result】The optimal compound amoxicillin and sulbactam sodiuma nanoemulsion consisted of 1% amoxicillin,0.5% sulbactam sodiuma,2.5% cinnamaldehyde,6.25% PEG400,18.75% RH-40,and 71% distilled water.The propotion of amoxicillin to sulbactan sodium was 2∶1.The nanoemulsion particle was spherical with the particle size of 13.41 nm and the polydispersity index (PDI) of 0.188.It had good physical stability.【Conclusion】Amoxicillin and sulbactam sodium nanoemulsion was prepared successfully. |
| Key words: amoxicillin sulbactam sodium nanoemulsion pseudoternary phase diagram |
