| 摘要: |
| 【目的】研究氯甲烷增强左旋氧氟沙星（Levofloxacin）超声降解的效果。【方法】利用JY92-Ⅱ超声波细胞粉碎装置，研究氯甲烷的类型（包括CH2Cl2、CHCl3、CCl4）、添加量以及超声波功率、溶液初始pH值等因素对超声降解左旋氧氟沙星效果的影响，并结合HPLC和TOC方法进一步分析降解效果。【结果】与左旋氧氟沙星单独超声相比，氯甲烷一定程度上提高了其超声降解率，其中CCl4明显提高了超声降解率。超声波功率为195 W，CCl4添加量为体积分数0.3%，pH不调节（7.16），反应35 min，左旋氧氟沙星的降解率达到43.36%。CHCl3和CCl4添加量在0.0%～0.3%，降解率随着添加量的增加而提高。超声波功率为65～195 W时，随着超声波功率增加，降解率明显提高。pH值对超声降解效果影响明显，pH=7.16（不调节）时降解率最高。HPLC图谱表明，CHCl3和CCl4在增强超声降解左旋氧氟沙星的过程中，同时有2种产物生成。TOC测定结果表明，超声20 min，CCl4完全矿化，左旋氧氟沙星的矿化作用不明显。【结论】氯甲烷可有效增强左旋氧氟沙星的超声降解效果，其中CCl4的效果非常明显。 |
| 关键词: 氯甲烷 超声 降解 左旋氧氟沙星 HPLC TOC |
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| 基金项目:国家自然科学基金项目（51009115）；陕西省科技计划项目（2010JQ5008） |
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| Enhancement of chloromethane on ultrasonic degradation of levofloxacin |
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| Abstract: |
| 【Objective】The ultrasonic degradation of levofloxacin in water with chloromethane enhancement was investigated.【Method】Sonication was performed with JY92-Ⅱ ultrasonic generator,and the effects of chloromethane type,adding dosage,ultrasonic power,and initial pH value of solution on degradation of levofloxacin were discussed.And the reactions were further examined by HPLC and TOC analysis.【Result】The results indicated that the ultrasonic degradation of levofloxacin was enhanced by addition of chloromethane to a certain extent,and the effect of CCl4 was notable.The degradation efficiency increased from 0.617% to 43.36% in 35 min with CCl4 dosage changed from 0.0% to 0.3% when ultrasonic power was 195 W,and pH was not buffered (7.16).The efficiency of ultrasonic degradation of levofloxacin in presence of CCl4 and CHCl3 increased with their adding dosage of 0.0%-0.3%.HPLC analysis showed that two main by-products were simultaneously produced during the ultrasonic degradation of levofloxacin in presence of CHCl3 and CCl4.TOC removal test showed that CCl4 decomposed totally in 20 min,but mineralization of levofloxacin was not obvious.【Conclusion】Chloromethane could effectively enhance ultrasonic degradation of levofloxacin. |
| Key words: chloromethane ultrasonic degradation levofloxacin HPLC TOC |
