| 摘要: |
| 从DNA甲基化修饰、组蛋白甲基化和乙酰化修饰、基因印记和RNA干扰等几个方面，综述了表观遗传学的基本机制及其对哺乳动物生殖细胞发育分化的影响。表观遗传学对于动物机体生长、代谢及功能的正常维持具有重要作用，其中任何方面的异常都会导致体细胞和生殖细胞的生长分化调控失常，甚至引发疾病。 |
| 关键词: 表观遗传学 甲基化 组蛋白 生殖细胞 |
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| 基金项目:国家自然科学基金项目（30200137，30972097）；教育部重点科研项目(109148)；中国博士后基金项目（20080431253）；中国博士后特别科学基金特别资助项目(200801438)；留学回国人员科研启动费（14110101）；陕西省科技攻关项目(2008K02 05)；西北农林科技大学青年学术骨干支持计划项目（01140301） |
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| Advances in the epigenetics and the differentiation and development of germ cells |
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| Abstract: |
| We reviewed the fundamental mechanism of epigenetics and its effects on the differentation and development of germ cells,which involves DNA methylation,histone acetylation and methylation,gene imprinting,RNA interference,and so on.Epigenetics is mainly on the study of the heritable phenotype changes which is not strictly dependent on DNA sequence.It plays an important role in the specification and differentiation of germ cell.These disorders can affect the renewal and differentiation of normal and germ cells,or even cause human diseases. |
| Key words: Epigentics methylation histone germ cell |
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