| 摘要: |
| 【目的】 研究染料木素（Genistein,Gen）对实验性Ⅱ型糖尿病大鼠模型血糖和血脂的影响。【方法】 用高脂饲料+小剂量链尿左菌素（50 mg/kg）腹腔注射的方法建立Ⅱ型糖尿病大鼠模型。将Ⅱ型糖尿病大鼠分成6个组，分别为Ⅱ型糖尿病模型组，Gen高、中、低剂量治疗组(Gen用量分别为30，18，9 mg/(kg·d))、Tween-80对照组及饮食调整组(Gen 30 mg/(kg·d))，另取正常大鼠作为正常对照组（Control组）。给药6周后采血测定所有试验大鼠的糖耐量、空腹血糖、血清胰岛素、血清总胆固醇（TC）、血清甘油三酯（TG）、血清高密度脂蛋白胆固醇（HDL-C）及血清低密度脂蛋白胆固醇（LDL-C）、肝糖原和肌糖原含量。【结果】 Gen能明显降低Ⅱ型糖尿病大鼠血清胰岛素水平，改善糖耐量，明显降低TC、TG、LDL-C、肝糖原和肌糖原含量，升高HDL-C及HDL-C/LDL-C比值。【结论】染料木素可有效纠正Ⅱ型糖尿模型大鼠的胰岛素抵抗和脂质代谢紊乱，改善肝脏和肌肉组织在糖代谢过程中的中转作用和糖耐量异常状况。 |
| 关键词: 染料木素 糖耐量 Ⅱ型糖尿病 血脂 肝糖原 肌糖原 SD大鼠 |
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| 基金项目:陕西省科技攻关计划项目（2005K14-G3-3） |
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| Effect of genistein to FPG and blood lipids on type Ⅱ diabetes rats |
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| Abstract: |
| 【Objective】The study investigated the effect of Genistein on FPG and blood lipids of type Ⅱ diabetes rats.【Method】 The type Ⅱ diabetes rats were induced by high calorie feeding and small dose injection of STZ.Ⅱ were randomly divided into 6 groups:type Ⅱ diabetic model group, genistein high,intermediate and low dose treated groups (Gen is 30,18,9 mg/(kg·d) respectively), food adjusted group (Gen 30 mg/（kg·d）) and tween-80 control group.In addition,other normal SD rats were used as control group.The levels of FPG,serum insulin，TC，TG，HDL-C，and LDL-C were measured at the end of week 6.【Result】 Genistein can significanly decrease 2-DM rats blood sugar,the content of serum insulin，TC，TG，and LDL-C while increase the content of the blood serum HDL and the ratio of HDL- C/LDL-C.【Conclusion】 Genistein can correct the level of insulin resistance and lipid metabolism disorder,improve key position of liver and muscle tissue in glucose metabolism and impaired glucose tolerance in 2-DM IR rats. |
| Key words: genistein glucose tolerance type Ⅱ diabetes mellitus (2-DM) blood lipids liver glycogen muscle glycogen SD rat |
