| 摘要: |
| 为了探索细辛素的构效关系,为创制新农药提供线索,以芝麻酚为原料合成了细辛素及其6种衍生物,并对其生物活性进行了测定。结果表明,3d、3e、3f为新化合物,未见文献报道,所有化合物的结构均经1H NMR、IR确认。生物活性测试结果表明,所有化合物均具有一定的杀虫活性,其中化合物3b和3g杀虫活性最显著,校正死亡率达到90%。 |
| 关键词: 细辛素 衍生物 生物活性 |
| DOI： |
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| 基金项目:西北农林科技大学校长专项基金项目（130709） |
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| Synthesis and bioactivity of sarisan and its derivatives |
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| Abstract: |
| In order to investigate structure-activity relationship analysis of sarisan and therefore provide a clue for creation of new pesticide, Sarisan and its 6 derivatives are synthesized from sesamol, of which 3d, 3e and 3f are first studied. Their structures were characterized by ^1 H NMR and IR. The biological activity tests showed that all of the compounds exhibited insecticidal activity,of which 3b and 3g are significant.The study is helpful to structure-activity relationship analysis of sarisan. |
| Key words: sarisan derivatives biological activity |
