| 摘要: |
| 报道了对羟基苯甲醛与盐酸羟胺、甲酸钠在质量分数88%～77.5%的甲酸中反应合成对羟基苯甲腈的新方法,考察了原料配比、反应时间、甲酸用量及浓度对反应收率的影响。结果表明,合成目标物的适宜工艺条件为:对羟基苯甲醛、盐酸羟胺与甲酸钠的物质的量之比为1.0∶1.2∶1.2,对羟基苯甲醛与甲酸用量之比为1.0 mol∶0.8 L,回流时间为30 min,收率可达88.6%。 |
| 关键词: 对羟基苯甲腈 对羟基苯甲醛 腈化 合成方法 |
| DOI： |
| 分类号: |
| 基金项目:西北农林科技大学青年科研专项基金 |
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| Study on the synthetic method of p-hydroxybenzonitrile |
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| Abstract: |
| The compound p-hydroxybenzonitrile was synthesized by the reaction of p-hydroxybenzaldehyde with hydroxylamine hydrochloride and sodium formate in 88%-77.5% formic acid solution.The influences of some factors on yield of p-hydroxybenzonitrile were investigated.The optimum reaction conditions were as followings:the molar ratios of p-hydroxybenzaldehyde to hydroxylamine hydrochloride and sodium formate are 1.0∶1.2∶1.2,the proportion of amount of p-hydroxybenzaldehyde to volume of formic acid is 1.0 mol∶0.8 L,the refluxing time is 30 min,and the yield attains 88.6%.The results showed that the method has a feature of lower cost,higher yield and less pollution. |
| Key words: p-hydroxybenzonitrile p-hydroxybenzaldehyde cyanation synthesis |
