| 摘要: |
| 新受精卵超越早期分裂阶段必需胚胎基因转录(ZGA)的重新起动与续后调控,在各类动物早期卵裂过程的胚胎基因转录起动精确时间是可变的,涉及染色质结构成分、调控元件(顺/反式)、RNA降解、DNA复制、修饰或加工作用、卵子发生因子、合子钟及天然信号等多种因素,因此提出哺乳动物胚胎发育期胚胎基因激活表达的调控机制。 |
| 关键词: 合子型基因激活 胚胎发育 基因调控 |
| DOI： |
| 分类号:］ |
| 基金项目:陕西省自然科学基金资助项目(99SM05) |
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| Regulating mechanism of zygotic gene activation in embryonic development |
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ZHU Xin chan,ZHANG Yong,ZHU Xin chan,ZHANG Yong
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| Abstract: |
| General development of a newly fertilized egg beyond early cleavage requires the de novo initiation and subsequent regulation of embryonic gene transcription.The precise timing of the onset of embryonic transcription in variety animals varies during early cleavage divisions.It is related to regulation of more factors,including chromatin structure components,regulating elements (cis-/trnas-),RNA degradation,DNA replication,modification and processing,oogenetic factors,zygotic clock,natural signal etc.There is,therefore,the regulating mechanism on the timing and control of embryonic gene expression during development,and its regulating mechanism. |
| Key words: zygotic gene activation (ZGA),embryonic development,gene regulation |
