| 摘要: |
| 三组（12只）成年奶山羊分别以每周一次口服不同剂量的亚硒酸钠，历时7周，测定其血液与组织硒的动态变化与分布状态，探讨硒含量变化的诊断价值。结果表明，血液硒含量与服硒总量呈正相关，动物起病、中毒和致死效应阶段的临界值分别为：0.4，0.6和1.6μg·mL-1；中毒羊组织硒含量依次为肝脏、肾脏、肺脏、脾脏、心脏和大脑，对照羊依次为肾脏、肝脏、脾脏、肺脏、大脑和心脏；血液与组织硒含量变化可作为奶山羊硒中毒病的诊断指标。 |
| 关键词: 奶山羊，硒中毒，实验室诊断，血液，组织，硒含量 |
| DOI： |
| 分类号:S858.266.9 |
| 基金项目:国家教委资助优秀年轻教师基金项目 |
|
| The Changes in Selenium Levels of Blood and Tissues of Selenosis in Milk Goats |
|
Li Guoqin Wang Jianhua Cao Guangrong Li Shaojun
|
| Abstract: |
| Three groups of adult milk goats were orally administrated with different
doses of sodium selenite weekly for seven weeks.The dynamic changes in the blood selenium and the distributional states of the tissue selenium were determined.The diagnostic values of changes in selenium concentration were diseussed.The results showed
that the boold selenium concentrations were in the positive correlation with the total
amount of selenium administrated:the limits of the blood selenium levels were correspondingly 0.4,0.6 and 1.6 μg·mL-1 at the pathoformic,poisoning and lethal phases.
The order of selenium concentrations of the tissues was liver,kidneys.lungs,spleen
myocardium and brain in the intoxicated goats.In the control of goats,the order was
kidneys,liver,spleen.lungs,brain and myocardium.The changes in the selenium concentrations of the blood and tissues can be used as the dignostic standard of selenium
poisoning in the milk goats. |
| Key words: milk goat.selenosis,lab diagnosis,blood.tissue,selenium level |
