| 摘要: |
| 8只成年奶山羊快速静注20％SMZ—Na注射液100mg/kg(SMZ计)经二周后,再以相同剂量肌注该制剂,均于注射后12小时内不同时间采血,用Annino法测定了SMZ血药浓度,药——时曲线最佳方程为:Civ=7.07e-4.1077t)+18.90e-0.6175t)和Cim=14.23(e-0.3552t)-e-1.7345t))肌注生物利用度(F)为86.39%,比文献记载绵羊口服SMZ的F(27%)高2.2倍,其它动力学参数为t1/2(β和KE),11.4和2.02h,Vd,503和822ml/kg;肌注CM和tM分别为6.39mg/100ml和1.38h。据单剂量参数(τ按6和8h)预报了重复给药的参数。 |
| 关键词: 磺胺甲异噁唑,生物利用度,药代动力学,奶山羊 |
| DOI： |
| 分类号: |
| 基金项目:中国科学院科学基金资助项目 |
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| STUDIES ON THE BIOAVAILABILITY AND PHARMA-COKINETICS OF SULFAMESOXAZOLE (SMZ) IN MILK GOATS |
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Hu Wenjie Liu Qingyu Chen Shijun: Wang Lin Qin Ning
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| Abstract: |
| The bilavailability and the pharmacokinetics of SMZ in 8 adult normal milk goats’ were studied. 100mg/kg wt. of SMZ was administrated by intravenous (i , v) and intramuscular (i.m.) injection, in two separate experiments for 2 weeks. Blood samples were collected at the different time within 12 hours after the drug was given. The blood concentration-time curves of the drug fitted the two-compartment ( i v) and sigle-compartment ( i.m.) open model, Ci v=7.07e-4.677t+18.90e-0.6175t and Ci.m.=14.23(e-0.3553t+e-1.7240t The bioavailability was 86.39%. The other parameter values were described as follows: t1/2 (β＆Ke),1.14±0.17 and 2.02±0.42h;AUC,33.40±7.09 and 30.4±4.48mg·h/100ml;Vd,503.0±50.0 俺的820.0±117.0ml/kg;Cl 314±82 and 287±43 ml.kg-1·h-1;CM,6.79±0.77mg/100ml;tM, 1.28±0.37h.The results showed that SMZ is a kind of shortaction sulfdrug in milk goats but the bioavailability is high following i.m. injection. The 20% SMZ-Na injection made by Shanghai Pharmaceutical Factory is stuitable. |
| Key words: Sulfamethoxazole(SMZ),Bioavailabitity Pharmacokinetics,milk goats |
